B-natriuretic peptide serum levels in neonates with persistent pulmonary hypertension

Abstract Background Better management of persistent pulmonary hypertension neonates (PPHN) required new markers that can predict the response patient to treatment and thus influence medical decision avoid short-term long-term adverse effects. Hence, we aimed evaluate B-natriuretic peptide (BNP) serum levels in with PPHN correlate its disease severity treatment. Patients methods The study included 60 (30 patients 30 healthy subjects). BNP was assessed, using ELISA technique, at admission after 4 days Results Initial were significantly higher compared controls ( p < 0.001). mild showed lower moderate severity, while decreased comparison severe cases group who remission had pre-treatment post-treatment levels, incomplete remission. strong positive correlations artery pressure (PAP) oxygenation index (OI) before r = 0.9, 0.001 0.85, 0.001), PAP 0.6, 0.001) OI Analysis ROC curve revealed an AUC 0.83with CI 0.7–0.98 0.003. Conclusions may play a role pathogenesis PPHN, level be used as marker detect